The loss of antigens on the surface of or within mammalian cells is a source of error and bias in antibody based detection. Antigens that become down-regulated due to a variety of factors can result in missed detections that lead to false negatives. Below are some literature examples of this phenomenon in a variety of applications.
Papers describing antigen loss in mammalian cells
- Loss of red cell A, B, and H antigens is frequent in myeloid malignancies - Link
- Clinical implication of HLA class I expression in breast cancer - Link
- beta2-Microglobulin mutations, HLA class I antigen loss, and tumor progression in melanoma - Link
- Interactions of HIV-1 with antigen-presenting cells - Link
- Hepatitis B Virus e Antigen Loss during Adefovir Dipivoxil Therapy Is Associated with Enhanced Virus-Specific CD4+ T-Cell Reactivity - Link