There are many applications that benefit greatly from a label-free approach. Fundamentally, such an approach allows researchers to ask questions without the bias of antibody or genetic labels.
Infectivity studies, viral vectors, adventitious viruses, and correlates of protection
T-Cell activation, tumor cell, tissue, and circulating tumor cell (CTC) identification and characterization
Viral and bacterial infection of mammalian cells
Pre-clinical drug candidate screening, toxicology, and cell biology
Rapid detection and quantitation of viral vector production of proteins and antibodies during R&D and manufacturing. For viral safety, the rapid detection of adventitious viruses in bioreactors and production processes.
Measure changes in optical forces and cytoskeletal changes (deformability) for differentiated and dedifferentiated cells
Other label-free applications
Identify and quantify changes in cellular properties upon modification of cellular genome (gene knock-outs/ins)
Measurement of apoptosis and macrophage activity and disfunction
Changes in cellular phenotype due to epigenetics require label-free methods of analysis to understand changes happening outside of the genome
Quantify effects of radiation on cells without labels