Radiance® Single Cell Analysis Instrument

What is Radiance®?

Radiance® by LumaCyte delivers real time, label free, single cell analytics for quantitative cellular characterization — enabling deeper insights into cell health, predictive viability, cellular response metrics, and functional potency.

This advanced cellular PAT platform is redefining biomanufacturing by helping production scientists rapidly assess the quality of cellular starting materials and precisely optimize critical workflows in the production of complex lifesaving biotherapeutics. Powered by robust multivariate and multiattribute analytics, Radiance® applies machine learning to deliver predictive insights with Time to Result (TTR) in minutes—giving teams the speed and intelligence needed to make informed decisions, faster.

At its core is Laser Force Cytology™ (LFC™)—a proprietary technology that measures optical and fluidic forces acting on cells within a microfluidic environment to reveal intrinsic biochemical and biophysical changes. Subtle shifts in cell behavior are precisely captured through the Radiance® automated workflow, enabling developers to monitor product quality attributes in-process and via offline release and potency assays.

Manufacturing success and consistency are foundational to FDA approvals. Radiance® empowers developers and sponsors with advanced GMP analytics to proactively mitigate risk, streamline technical transfer, and ensure robust comparability across clinical and commercial scale. Through continuous monitoring of critical process parameters and product quality attributes, Radiance® supports both FDA-aligned real time release testing strategies within the broader CMC framework and potency assurance approaches designed specifically for cellular and gene therapies. By delivering predictive insights through multiattribute analytics, Radiance® helps production teams drive process reliability, therapeutic integrity, and lifecycle confidence.

Single cell analysis instrument using LumaCyte’s Laser Force Cytology™

Key Features

Radiance® offers key features that set it apart from other cell analysis instruments, delivering real-time insights with label-free technology. These features include:

96-well Plate Format

Radiance® has a 96-well plate format allowing for unattended, automated processing and single cell analysis (100k cells in 200μL).

Flexibility and Power

Radiance® is fully programmable via Illuminate™ software suite, giving users maximum flexibility and power for automating sample analyses.

Viable Cells

Radiance® analyzes both adherent and suspension cells, providing unparalleled flexibility for diverse cell studies.

Sensitivity

Sensitive to phenotypic changes including: early viral infection, cell differentiation, viability, transfection, biochemical exposure, etc.

Multivariate Analysis

Radiance® measures 20+ parameters per cell including velocity (optical force), shape, and deformability. Machine learning algorithms leverage this multivariate data to uncover hidden patterns and predict cellular behavior across complex workflows.

Small Benchtop Design

Benchtop design with a footprint (16″W × 24″D x 29″H) small enough to fit on any laboratory bench.

Why Radiance® as Your Advanced Analytical Solution?

Radiance® delivers unbiased single-cell analysis that helps developers transform bioprocesses across cell therapy, gene therapy, and vaccine manufacturing workflows. By integrating advanced cellular Process Analytical Technology (PAT) and machine learning/AI-driven analytics, Radiance® enables real-time control and optimization of important biomanufacturing processes, ensuring consistent product quality and regulatory compliance.

Cellular analysis without bias, allowing developers to transform bioprocesses within cell therapy, gene therapy, and vaccine development and manufacturing workflows.

Use Cases

Cell Therapy

Real-time, label-free cell characterization providing new process insights for autologous and allogeneic cell therapies, stem cell and phenotypic characterization of cells.

Gene Therapy

Accurate and precise AAV transfection and transduction monitoring enabling a more nuanced understanding of gene therapy potency and paving the way for personalized and optimized therapeutic strategies.

Biomanufacturing

Automated workflow and analysis that enables real-time monitoring of key product quality attributes and ensures improved process and product consistency.

Vaccines

Rapid viral infectivity for vaccine R&D, process development and optimization, manufacturing formulations, potency and neutralization assays.

LumaCyte’s Illuminate™ and ReportR™ software suites provide powerful, fully integrated solutions for single cell analysis—engineered specifically for scientists and bioengineers working in regulated environments. Built on the proprietary Laser Force Cytology™ (LFC™) platform, these tools streamline instrument control, data acquisition, and automated analysis to support precision and compliance across biomanufacturing workflows.

The suite includes three core applications—Instrument, Analyzer, and Sampler—each designed to optimize control and workflow efficiency. Illuminate™ is 21 CFR Part 11 compliant, offering secure login management, audit trails, and integration with GMP-aligned processes. ReportR™ is also fully GMP compliant, enabling cloud-based, automated cell analysis and standardized report generation that meets rigorous regulatory standards.

Together, Illuminate™ and ReportR™ power Radiance®’s advanced capabilities, ensuring consistency, accuracy, and operational excellence in both clinical and commercial settings.

Learn More About Illuminate

Ready to Improve Your Single Cell Analysis?

Whether you’re optimizing biomanufacturing workflows or advancing therapeutic development, Radiance® gives you the real-time, label-free insights you need to succeed. With predictive analytics and machine learning at its core, Radiance® helps you stay ahead of process variability and unlock new levels of control and efficiency. Connect with our team to explore how Radiance® can support your specific applications in cell therapy, gene therapy, vaccine development, and more.

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